Trial of warfarin maintenance dose prediction.
نویسندگان
چکیده
منابع مشابه
Flexible induction dose regimen for warfarin and prediction of maintenance dose.
Fifty patients with venous thromboembolic disease being treated by heparin infusion received a three day warfarin induction regimen tailored according to the prothrombin time (British comparative ratio) measured on days 2 and 3. A prediction of the final maintenance dose of warfarin was made on the basis of a prothrombin time measured on day 4. All patients were safely anticoagulated by day 6, ...
متن کاملFrequency of two VKORC1 gene variants and its correlation with warfarin maintenance dose
Warfarin is a commonly-prescribed anticoagulant used to treat and prevent thromboembolic events. The requirement for varying doses of warfarin depends on genetic and environmental components. In this study, the frequency of two single-nucleotide polymorphic variants of the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene (1173 C>T (rs9934438) and 3730 G>A (rs7294)) and its correlatio...
متن کاملA Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction
A number of a priori warfarin dosing algorithms, derived using linear regression methods, have been proposed. Although these dosing algorithms may have been validated using patients derived from the same centre, rarely have they been validated using a patient cohort recruited from another centre. In order to undertake external validation, two cohorts were utilised. One cohort formed by patients...
متن کاملGenetic factors for warfarin dose prediction.
stolic dysfunction either in asymptomatic or symptomatic patients, that is, stage B or C of the definition of heart failure, according to the classification of the American Heart Association/American College of Cardiology task force for the diagnosis and management of chronic heart failure (3 ). One important finding of our metaanalysis (1 ) is represented by the heterogeneity of data published...
متن کاملFactors determining the maintenance dose of warfarin in Chinese patients.
Chinese patients are reportedly more sensitive than Caucasians to the anticoagulant effect of warfarin. We examined warfarin dose requirements and their determinants in 151 Chinese out-patients on stable maintenance dose of warfarin with international normalized ratio of 2 to 2.5. Mean daily warfarin requirement was 3.3 +/- 1.4 mg, much lower than reported doses in Caucasian patients. The most ...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1995
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.26.177